What is the recommended treatment for patellofemoral pain syndrome?

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Last updated: June 23, 2025View editorial policy

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From the Guidelines

The recommended treatment for patellofemoral pain syndrome primarily involves physical therapy focusing on quadriceps and hip strengthening exercises, particularly targeting the vastus medialis obliquus muscle, as supported by the most recent and highest quality study 1.

Key Components of Treatment

  • Patients should perform exercises like straight leg raises, wall squats, and step-ups for 6-8 weeks, with 3-4 sessions per week, as part of a comprehensive approach to address the underlying biomechanical issues 1.
  • Pain management can include over-the-counter NSAIDs such as ibuprofen (400-600mg three times daily) or naproxen (220-440mg twice daily) for short periods during flare-ups.
  • Activity modification is essential—patients should temporarily reduce activities that aggravate symptoms, like running, jumping, or climbing stairs.
  • Supportive measures include proper footwear, possibly with over-the-counter orthotics, and patellar taping or bracing in some cases.
  • Education should underpin all interventions, adjusted to reflect the needs of the person, and may seek to challenge inaccurate beliefs, build confidence and understanding of the diagnosis, and promote autonomy and reduce fear 1.

Additional Considerations

  • Prefabricated foot orthoses should be prescribed to those who respond favourably to treatment direction tests and be customised for comfort by modifying density and geometry 1.
  • Movement/running retraining can be considered in those with symptoms reasoned to be associated with assessment findings aligning with the intervention.
  • Taping should be considered for people where rehabilitation is hindered by elevated symptom severity and irritability 1.

Expected Outcomes

Most patients see significant improvement within 4-6 weeks of consistent therapy, though complete resolution may take 3-6 months, as noted in the study 1.

From the Research

Treatment Options for Patellofemoral Pain Syndrome

The recommended treatment for patellofemoral pain syndrome (PFPS) includes:

  • Physiotherapy, which is the most common physical intervention and includes specific vastus medialis obliquus or general quadriceps strengthening and/or realignment procedures (tape, brace, stretching) 2
  • A multimodal approach, which combines thrust and nonthrust manipulation, trunk and hip stabilization exercises, patellar taping, and foot orthotics 3
  • Strength training and stretching programs, which have traditionally been the mainstay of patient treatment 4
  • Quadriceps and hip strengthening combined with stretching in a structured physiotherapy program, which is the most effective treatment for reducing knee pain symptoms and improving functionality in patients with PFPS 4

Efficacy of Treatment Options

Studies have shown that:

  • Physiotherapy interventions have significant beneficial effects, but comparison with a placebo group is required to determine efficacy 2
  • A 6-week regimen of physical therapy is efficacious for alleviation of patellofemoral pain 5
  • A multimodal approach can result in decreased pain and clinically significant improvement in function, with gains maintained at 6-month follow-up 3
  • Strength training and stretching exercises are effective treatment options for runners with PFPS 4
  • Surgical and pharmacologic therapies are not effective for the management of patients with PFPS 4

Adjunctive Therapies

Adjunctive therapies, such as:

  • Proprioceptive training
  • Orthotics
  • Taping
  • Biofeedback devices may offer benefits, but do not show a significant benefit when used alone in patients with PFPS 4, 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

A systematic review of physical interventions for patellofemoral pain syndrome.

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2001

Research

Management of patients with patellofemoral pain syndrome using a multimodal approach: a case series.

The Journal of orthopaedic and sports physical therapy, 2008

Research

A review of the management of patellofemoral pain syndrome.

The Physician and sportsmedicine, 2013

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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