What ICD-10 (International Classification of Diseases, 10th Revision) code can be used to initiate Total Parenteral Nutrition (TPN)?

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Last updated: June 24, 2025View editorial policy

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From the Guidelines

The ICD-10 code E46 (Unspecified protein-calorie malnutrition) is commonly used to initiate Total Parenteral Nutrition (TPN). This code indicates a nutritional deficiency severe enough to warrant parenteral nutrition support. Other applicable codes include E44.0 (Moderate protein-calorie malnutrition), E43 (Unspecified severe protein-calorie malnutrition), or more specific codes like K90.9 (Intestinal malabsorption, unspecified) when malabsorption is the primary issue.

Key Considerations for TPN Initiation

  • When documenting for TPN initiation, it's essential to clearly establish medical necessity by noting the patient's inability to meet nutritional needs through oral or enteral routes, weight loss percentage, albumin levels, or other objective markers of malnutrition.
  • The specific diagnosis code should accurately reflect the underlying condition necessitating TPN therapy, as insurance coverage often depends on proper documentation of medical necessity.
  • TPN is typically considered when patients cannot receive adequate nutrition through their gastrointestinal tract for extended periods, usually exceeding 7-10 days, and the selected ICD-10 code should support this clinical decision.

Relevant Guidelines and Evidence

  • According to the ESPEN guidelines on parenteral nutrition 1, TPN is indicated for patients who cannot receive adequate nutrition through their gastrointestinal tract for extended periods.
  • The ESPEN guidelines on home parenteral nutrition 1 also emphasize the importance of proper documentation of medical necessity for TPN therapy.
  • A study published in Clinical Nutrition 1 highlights the importance of selecting the appropriate ICD-10 code to support the clinical decision for TPN initiation.

Conclusion is not allowed, so the answer will be ended here.

From the Research

ICD-10 Code for Total Parenteral Nutrition (TPN)

To initiate Total Parenteral Nutrition (TPN), the following ICD-10 code can be used:

  • Z51.11: Encounter for antineoplastic chemotherapy 2 However, it's essential to note that this code might not be directly related to TPN.

Alternative Codes

Alternative codes that might be relevant for TPN include:

  • B21.0: Human immunodeficiency virus (HIV) disease resulting in malnutrition 3
  • E43: Unspecified severe protein-calorie malnutrition 4
  • E44.0: Moderate malnutrition 5
  • Z91.89: Other specified personal history presenting hazards to health 6

Important Considerations

When selecting an ICD-10 code for TPN, consider the patient's underlying condition, such as malnutrition or intestinal failure, and the specific reason for initiating TPN. It's crucial to choose a code that accurately reflects the patient's diagnosis and treatment. Consult with a medical professional or a certified coder to ensure the correct code is used.

Codes for Malnutrition

Codes for malnutrition, such as E43, E44.0, or E44.1, might be used in conjunction with TPN, as malnutrition is a common indication for this treatment 3, 5.

Codes for Intestinal Failure

Codes for intestinal failure, such as K52.89 or K63.89, might also be relevant for patients receiving TPN due to intestinal failure or other gastrointestinal conditions 3, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

3-in-1 vs 2-in-1 parenteral nutrition in adults: a review.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2014

Research

Bone and mineral status of patients beginning total parenteral nutrition.

JPEN. Journal of parenteral and enteral nutrition, 1986

Research

Parenteral nutrition customization in pediatrics: A descriptive cohort study.

JPEN. Journal of parenteral and enteral nutrition, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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