Can amlodipine (calcium channel blocker) tablets be split in half?

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Last updated: June 24, 2025View editorial policy

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From the Research

Most amlodipine tablets can be safely split in half, but it's crucial to consult with your healthcare provider or pharmacist first, especially for extended-release or special formulations. Amlodipine, commonly sold under brand names like Norvasc, is typically available in 2.5 mg, 5 mg, and 10 mg tablets, and many formulations have a score line specifically designed to help with splitting 1. This can be useful if your doctor has prescribed a dose between the standard tablet strengths or if you need to adjust your dose. When splitting tablets, use a pill cutter rather than a knife or scissors to ensure an even split and accurate dosing.

Important Considerations

  • Extended-release or special formulations of amlodipine should not be split as this could alter how the medication is released in your body 2.
  • The ability to split amlodipine relates to its pharmacology - as a calcium channel blocker with a long half-life, small variations in dose that might occur with splitting generally won't significantly impact its effectiveness in controlling blood pressure or treating angina 3.
  • It's essential to discuss medication administration with your healthcare provider or pharmacist to clarify the dosing schedule and ensure you're taking the medication correctly 2.

Key Points to Remember

  • Always consult with your healthcare provider or pharmacist before splitting any medication to confirm it's appropriate for your specific prescription.
  • Use a pill cutter for splitting tablets to ensure accuracy and safety.
  • Be aware of the formulation of your amlodipine tablets to avoid splitting extended-release or special formulations.

References

Research

[Tablet splitting].

Therapeutische Umschau. Revue therapeutique, 2006

Research

Crushing or splitting medications: unrecognized hazards.

Journal of gerontological nursing, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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