From the Research
Leukopenia can be caused by several nutritional deficiencies, primarily copper, iron, vitamin B12, and folate, which are essential for DNA synthesis, cell division, and white blood cell production. The most recent and highest quality study 1 suggests that iron deficiency can cause leukopenia, and treatment with oral iron supplements can correct this condition. Other studies 2, 3, 4, 5 also support the role of nutritional deficiencies in causing leukopenia, including copper, vitamin B12, and folate deficiencies. Key points to consider include:
- Copper deficiency impairs white blood cell production and maturation, as seen in a case report of a patient with copper deficiency anaemia 2.
- Iron deficiency can cause leukopenia, as demonstrated in a study where a patient's neutropenia was corrected with oral iron supplements 1.
- Vitamin B12 and folate deficiencies can also cause leukopenia, as they are essential for DNA synthesis and cell division 3, 4, 5.
- Treatment involves identifying and correcting the specific nutritional deficiency through dietary changes or supplements, with regular blood tests to monitor improvement in white blood cell counts. In clinical practice, it is essential to consider these nutritional deficiencies as potential causes of leukopenia and to investigate and treat them accordingly to improve patient outcomes and quality of life.