Does Astaxanthin increase High-Density Lipoprotein (HDL) levels?

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Last updated: June 24, 2025View editorial policy

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From the Research

Astaxanthin has been shown to increase HDL levels, with doses of 6-12 mg daily for 8-12 weeks potentially raising HDL levels by approximately 5-15%. The evidence for astaxanthin's effect on HDL levels is based on several studies, including a 2010 study published in Atherosclerosis, which found that astaxanthin administration at doses of 6,12, and 18 mg/day for 12 weeks increased HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia 1. Another study published in 2011 in Plant Foods for Human Nutrition found that astaxanthin supplementation reduced LDL cholesterol and apolipoprotein B, and improved oxidative stress biomarkers, but did not specifically report an increase in HDL levels 2. However, the most relevant and recent study, published in 2010, provides the strongest evidence for astaxanthin's effect on HDL levels 1. It is essential to note that astaxanthin should be used as a complement to established approaches like diet, exercise, and prescribed medications, rather than a replacement. Astaxanthin is a carotenoid antioxidant that appears to work by reducing oxidative stress and inflammation in the body, potentially enhancing reverse cholesterol transport. Before starting astaxanthin, it is crucial to consult with a healthcare provider, especially if you are taking other medications or have existing health conditions. Some people may experience mild side effects, such as digestive discomfort or skin pigmentation changes, but overall, astaxanthin is generally well-tolerated. Key points to consider when using astaxanthin for cholesterol management include:

  • Starting with a low dose and gradually increasing as needed and under medical supervision
  • Monitoring HDL levels and other lipid profiles regularly
  • Combining astaxanthin with other cholesterol-lowering strategies, such as diet and exercise, for optimal results
  • Being aware of potential interactions with other medications and health conditions.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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