Does Astaxanthin increase High-Density Lipoprotein (HDL) levels?

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Last updated: June 14, 2025View editorial policy

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From the Research

Astaxanthin may increase HDL levels, as suggested by a 2011 study published in Alternative Medicine Review, which found that astaxanthin lowered triglycerides and raised HDL-cholesterol in a trial 1. The evidence for astaxanthin's effect on HDL levels is mixed, but some studies suggest that it may have a positive impact.

  • Astaxanthin is a naturally occurring carotenoid with antioxidant properties that appears to influence lipid metabolism by enhancing reverse cholesterol transport and reducing oxidative stress.
  • The improvements in HDL levels are generally modest, typically showing increases of about 5-10% in HDL levels.
  • A 2011 study published in Plant Foods for Human Nutrition found that astaxanthin had positive effects on lipid profiles and oxidative stress in overweight subjects, although it did not specifically report an increase in HDL levels 2.
  • Another study published in 2019 in Oxidative Medicine and Cellular Longevity discussed the potential of astaxanthin as a mitochondrial-targeted antioxidant treatment in diseases and with aging, but did not specifically address its effect on HDL levels 3.
  • It's essential to note that lifestyle modifications like regular exercise, weight management, and a heart-healthy diet remain more established and effective approaches for improving HDL levels.
  • Consulting with a healthcare provider before starting any supplement regimen is advisable, especially for individuals on medications or with existing health conditions.

References

Research

Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.

Alternative medicine review : a journal of clinical therapeutic, 2011

Research

Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects.

Plant foods for human nutrition (Dordrecht, Netherlands), 2011

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