Do statins (HMG-CoA reductase inhibitors) improve plantar fasciitis?

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Last updated: June 24, 2025View editorial policy

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From the Research

Statin therapy is not recommended for the treatment of plantar fasciitis, as there is no evidence to support its effectiveness in improving this condition. The primary use of statins, such as atorvastatin, simvastatin, and rosuvastatin, is to lower cholesterol and reduce cardiovascular risk, not to treat musculoskeletal inflammatory conditions like plantar fasciitis 1.

Standard Treatment for Plantar Fasciitis

The standard treatment for plantar fasciitis includes:

  • Rest
  • Ice
  • Stretching exercises
  • Proper footwear with good arch support
  • Night splints
  • Physical therapy
  • Anti-inflammatory medications like ibuprofen or naproxen For persistent cases, corticosteroid injections, extracorporeal shock wave therapy, or in rare cases, surgery might be considered 2, 3.

Pathophysiology of Plantar Fasciitis

The pathophysiology of plantar fasciitis involves microtears and inflammation in the plantar fascia due to repetitive stress, which is not directly addressed by the mechanisms of action of statins. While statins do have some anti-inflammatory properties, these properties have not been shown to benefit plantar fasciitis specifically 4, 5.

Recommendation

The most effective treatment for plantar fasciitis is a combination of corticosteroid injections and controlled training, including strength training and stretching 3. This approach has been shown to be superior to other treatments, including physical therapy and orthotics, in reducing pain and improving function in patients with plantar fasciitis.

References

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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