From the Guidelines
Platelet gel is the term for Platelet-Rich Plasma (PRP) that is made into a gel. When PRP is activated, it forms a gel-like substance, which is referred to as platelet gel, as mentioned in the study by Harrison et al. 1. This transformation occurs when PRP is activated, releasing its bioactive proteins, including multiple growth and differentiation factors. The resulting platelet gel serves as a temporary matrix to assist repair of the injured tissue.
Key Characteristics of Platelet Gel
- It is a gel-like substance formed by activating PRP
- It has a fibrin scaffold that traps platelets and their growth factors
- It allows for a slower, more sustained release of bioactive proteins
- It can be used as a three-dimensional scaffold to promote tissue healing and regeneration
Clinical Applications of Platelet Gel
- Surgical procedures
- Wound healing
- Tissue regeneration The use of platelet gel has been discussed in the context of regenerative medicine, highlighting the need for standardization in the preparation and application of platelet-rich preparations, as emphasized by Harrison et al. 1.
From the Research
Definition of PRP Gel
- Platelet-rich plasma (PRP) that is made into a gel is commonly referred to as platelet-rich gel (PRG) 2.
- PRG is formed by activating PRP with a mixture of thrombin and calcium chloride, resulting in the release of numerous regulatory molecules to the injury site 2.
Formation of PRG
- The activator for PRP is a mixture of thrombin and calcium chloride, which when combined with PRP, forms a platelet-rich gel (PRG) 2.
- Alternatively, batroxobin can be used to induce gelation, which acts differently from thrombin and results in a slow release of growth factors 3.