From the Guidelines
Platelet-rich plasma (PRP) gel is a regenerative treatment in dermatology that promotes tissue healing and rejuvenation, and its use is supported by recent studies, such as 1, which demonstrate its effectiveness in various dermatological conditions.
Overview of PRP Gel in Dermatology
PRP is derived from a patient's own blood, which is centrifuged to concentrate platelets that contain growth factors and cytokines. In dermatology, PRP is primarily used for:
- Facial rejuvenation
- Hair restoration
- Acne scarring
- Wound healing For facial applications, typically 3-4 treatments spaced 4-6 weeks apart are recommended, with maintenance sessions every 6-12 months. For hair loss, protocols often involve monthly treatments for 3-4 months, followed by maintenance every 3-6 months.
Mechanism of Action and Efficacy
The procedure involves drawing approximately 10-30ml of blood, processing it to isolate the platelet-rich portion, and then injecting or applying it topically to the treatment area. PRP works by releasing growth factors that stimulate collagen production, increase blood supply, and activate stem cells in the treated area. This biological mechanism accelerates healing and tissue regeneration, making it particularly effective for aging skin, androgenetic alopecia, and atrophic scars, as shown in studies such as 1 and 1.
Safety and Side Effects
Side effects are minimal since PRP uses the patient's own blood, though temporary bruising, swelling, and redness may occur at injection sites. Studies such as 1 and 1 have demonstrated the safety and efficacy of PRP in various dermatological conditions.
Recommendations for Use
The use of PRP gel in dermatology is recommended, particularly when combined with other treatments such as microneedling, as shown in study 1. Additionally, studies such as 1 provide guidelines for the preparation and administration of PRP for androgenetic alopecia, including the use of a manual double-spin method, performing a minimum of 3-5 sessions, and using a recommended dose of 5-7 mL PRP.
From the Research
Role of PRP Gel in Dermatology
The use of Platelet-rich plasma (PRP) gel in dermatology has gained significant attention in recent years due to its potential in treating various skin-related conditions. PRP is a platelet concentrate contained in a small volume of plasma, rich in growth factors that stimulate tissue repair and regeneration.
Applications of PRP Gel in Dermatology
Some of the key applications of PRP gel in dermatology include:
- Treatment of acne, alopecia, and skin ulcers 2
- Management of melasma, hyperpigmentation, and burns 2
- Skin rejuvenation and facial rejuvenation 3, 4
- Treatment of atrophic acne scars 5
- Promotion of collagen deposition and tissue regeneration 5, 3
Mechanism of Action
PRP gel works by stimulating collagen production, promoting tissue repair, and enhancing skin elasticity 3, 4. The growth factors present in PRP gel also help in keratinocyte and fibroblast proliferation, leading to improved skin texture and appearance.
Safety and Efficacy
Studies have shown that PRP gel is a safe and effective treatment option for various dermatological conditions 5, 3, 4. The use of autologous PRP gel reduces the risk of adverse reactions and transfusion-transmitted infections, making it an optimal therapy for patients 2.
Combination Therapies
PRP gel can be combined with other treatments, such as fractional laser therapy, to enhance its efficacy in skin rejuvenation 4. The combination of PRP gel with skin needling has also shown promising results in promoting collagen production and tissue regeneration 3.