From the Research
The recommended dose of ivermectin for dogs weighing 5-60 pounds is typically 6 micrograms per kilogram (mcg/kg) of body weight, administered orally once a month for heartworm prevention. For a 5-pound dog, this would be approximately 13.6 mcg, while a 60-pound dog would need about 163.3 mcg. Ivermectin is commonly used to prevent heartworm disease and treat certain parasitic infections in dogs. It works by paralyzing and killing parasites by affecting their nervous system.
Important Considerations
- Certain dog breeds with the MDR1 gene mutation (like Collies, Australian Shepherds, and related breeds) may be sensitive to ivermectin and require lower doses or alternative medications 1.
- Never use livestock formulations of ivermectin for dogs, as these are highly concentrated and can be dangerous.
- Always consult with your veterinarian before administering ivermectin, as the dosage may vary based on the specific condition being treated and your dog's individual health status.
Administration and Safety
- The medication is typically administered as a flavored chewable tablet or as part of a combination product that also controls other parasites.
- A study published in 2016 evaluated the pharmacokinetics and efficacy of ivermectin in dogs, but the dose used was 0.6μg/kg, which is lower than the typical recommended dose 2.
- Another study from 1992 found that the bioavailability of ivermectin was dose-dependent, with higher doses resulting in higher peak plasma levels 3.
- More recent studies have focused on the use of ivermectin in combination with other medications for the treatment of heartworm disease, such as a 2020 study that used a combination of imidacloprid, moxidectin, and doxycycline 4.
- A 2011 study evaluated the use of ivermectin in combination with doxycycline for the treatment of heartworm disease, and found that it was effective in reducing lung pathology 5.