From the Research
Berberine is the most effective herbal medication for treating Small Intestine Bacterial Overgrowth (SIBO), as evidenced by the most recent and highest quality study 1.
Treatment Protocol
For treatment, a typical herbal protocol involves taking berberine (400mg twice daily) for 2 weeks, as outlined in the BRIEF-SIBO study 1. This study aimed to evaluate the effect of berberine compared with rifaximin on SIBO patients, with a primary outcome of a negative breath test.
Mechanism of Action
Berberine works through its natural antimicrobial properties, modifying the gut microbiota and ameliorating intestinal inflammation in humans 1.
Combination Therapy
While other herbal medications like oregano oil, neem, and allicin (from garlic) have been suggested as potential treatments for SIBO 2, 3, 4, the most recent and highest quality study supports the use of berberine as a primary treatment option 1.
Dietary Modifications
It is essential to combine herbal treatments with dietary modifications that reduce fermentable carbohydrates to enhance effectiveness, as suggested by previous studies 2, 3, 4.
Consultation
Consult with a healthcare provider before starting this regimen, especially if you have other health conditions or take medications, to ensure the best possible outcome and minimize potential side effects.
Quality of Life
A comprehensive therapeutic approach, including pharmacological treatment, dietary intervention, and strategies to improve gut microbiota and intestinal permeability, can produce a sustained improvement in the quality of life of patients with SIBO, as shown in a recent real-world clinical practice study 5.