From the Research
Sermorelin can indirectly affect thyroid levels by stimulating the pituitary gland to produce more growth hormone, which in turn influences thyroid function through the complex interplay of the endocrine system. The effects of sermorelin on thyroid levels are typically modest and may include slight increases in thyroid hormone conversion, particularly the conversion of T4 (thyroxine) to the more active T3 (triiodothyronine) 1. This occurs because growth hormone can enhance peripheral conversion of thyroid hormones. The effect is generally not significant enough to cause thyroid dysfunction in people with normal thyroid function, but those with pre-existing thyroid conditions should be monitored. Some key points to consider include:
- Typical sermorelin dosing ranges from 100-500 mcg daily, usually administered as a subcutaneous injection before bedtime to align with the body's natural growth hormone pulse.
- Patients with thyroid disorders should have their thyroid levels checked before starting sermorelin and periodically during treatment.
- The relationship between growth hormone and thyroid function is bidirectional - thyroid hormones are also necessary for optimal growth hormone secretion and action, which explains why hypothyroid patients often have reduced growth hormone responses 2. It's essential to prioritize the monitoring of thyroid levels in patients with pre-existing thyroid conditions who are undergoing sermorelin treatment, as the effects of sermorelin on thyroid function can be variable and may require adjustments in treatment 3, 4.