Simple Hepatic Cyst: This is the most common diagnosis for a hepatic cyst, typically benign and asymptomatic, often discovered incidentally on imaging studies. It is a congenital or acquired fluid-filled lesion that does not communicate with the biliary tree.

Polycystic Liver Disease (PLD): Characterized by the presence of multiple cysts within the liver, often associated with polycystic kidney disease. It can lead to significant liver enlargement and potentially cause complications such as cyst rupture or hemorrhage.
Hepatic Hydatid Cyst: Caused by the parasitic infection Echinococcus granulosus, leading to cyst formation in the liver. It's more common in endemic areas and can cause symptoms due to the size of the cyst or its complications.
Biliary Cystadenoma/Cystadenocarcinoma: Rare, benign or malignant tumors of the biliary epithelium that can present as cystic lesions in the liver. They have the potential for malignant transformation and thus are important to distinguish from simple cysts.

Amebic Liver Abscess: Although less common, an amebic liver abscess can mimic a hepatic cyst on imaging. It is a serious condition caused by Entamoeba histolytica infection, requiring prompt treatment to prevent complications such as rupture.
Pyogenic Liver Abscess: A bacterial infection of the liver that can present as a cystic lesion. It is a medical emergency due to the risk of sepsis and requires immediate antibiotic treatment and possibly drainage.
Echinococcal Cyst Rupture: Rupture of a hydatid cyst can lead to severe allergic reactions, dissemination of the disease, or secondary infections, making it critical to diagnose and manage promptly.

Congenital Hepatic Fibrosis: A rare genetic disorder leading to fibrosis and cyst formation in the liver, often associated with other systemic manifestations such as renal disease.
Ciliated Hepatic Foregut Cyst: A rare, benign cystic lesion thought to arise from foregut tissue, usually asymptomatic but can cause complications if it becomes large or infected.
Mesenchymal Hamartoma: A rare, benign tumor of the liver that can present as a cystic mass, more common in children and often discovered incidentally.