What are the treatment options for Ehlers-Danlos syndrome?

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Last updated: June 26, 2025View editorial policy

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From the Research

Treatment options for Ehlers-Danlos syndrome (EDS) should prioritize a multidisciplinary approach, focusing on symptom management and preventing complications, with occupational therapy and bracing being the most effective options, as reported by 70% of patients showing improvement 1. The management of EDS requires a comprehensive strategy that addresses the various aspects of the condition, including pain, joint instability, and skin fragility.

  • Pain management typically includes over-the-counter medications like acetaminophen or NSAIDs for mild pain, while prescription medications such as tramadol or gabapentin may be used for more severe pain.
  • Physical therapy is essential and should include exercises to strengthen muscles around hypermobile joints, improve proprioception, and enhance overall stability.
  • Occupational therapy helps patients develop strategies for daily activities while protecting their joints.
  • For skin fragility, patients should avoid trauma, use mild soaps, moisturize regularly, and apply protective bandages when needed.
  • Joint protection measures include using braces or splints for unstable joints, avoiding hyperextension, and modifying activities to reduce joint stress. Some patients may require surgical interventions for complications like joint instability or organ issues, though surgery carries additional risks in EDS patients due to tissue fragility, as noted in studies discussing the challenges of managing EDS pain 2, 3. Psychological support is important as chronic pain and physical limitations can lead to anxiety and depression. Lifestyle modifications including regular low-impact exercise, proper sleep hygiene, and nutritional support can help manage symptoms and improve quality of life, with many patients also seeking complementary therapies like marijuana and physical therapy, which they find helpful in alleviating pain 4.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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