From the Research
Prednisone is not a recommended treatment for interstitial cystitis due to limited evidence and significant potential side effects. While corticosteroids like prednisone can reduce inflammation, the risks associated with long-term use, including immune suppression, weight gain, bone density loss, and blood sugar elevation, typically outweigh any potential benefits for IC patients 1.
Treatment Options for Interstitial Cystitis
More established treatment approaches for interstitial cystitis include:
- Pentosan polysulfate sodium (Elmiron)
- Amitriptyline
- Hydroxyzine
- Pain management medications
- Bladder instillations
- Physical therapy
- Dietary modifications to avoid trigger foods
Use of Corticosteroids in IC
Corticosteroids might occasionally be considered for short-term use in severe inflammatory flares when other treatments have failed, but this would be an exception rather than standard practice 2. The chronic nature of IC generally makes long-term steroid use inappropriate due to the significant side effect profile.
Developing a Comprehensive Treatment Plan
Patients with IC symptoms should work with urologists or urogynecologists who specialize in pelvic pain conditions to develop a comprehensive treatment plan tailored to their specific symptoms 3, 4. This approach allows for a personalized treatment strategy that can help manage symptoms and improve quality of life.
Evidence for Treatment Efficacy
Studies have shown that a combination of intravesical and systemic agents, such as hydrocortisone and heparin, along with oral bladder sedatives and systemic steroids, may be effective in treating interstitial cystitis 2. However, the use of prednisone specifically for IC is not well-supported by evidence, and its potential risks make it a less desirable treatment option 1, 5.