Chronic Liver Disease with Cirrhosis: This condition often presents with right upper quadrant (RUQ) pain due to liver enlargement or capsular stretching, and peripheral edema resulting from hypoalbuminemia and portal hypertension. The combination of these symptoms, especially in a patient with a history of liver disease or risk factors such as alcohol abuse or hepatitis, makes cirrhosis a leading consideration.

Heart Failure: Right-sided heart failure can cause peripheral edema and, if severe, can lead to liver congestion and RUQ pain. The mechanism involves backpressure into the hepatic veins, leading to liver enlargement and discomfort.
Nephrotic Syndrome: Characterized by significant proteinuria, hypoalbuminemia, and edema. While the primary symptom is edema, nephrotic syndrome can also lead to hypercoagulability, potentially causing renal vein thrombosis, which might indirectly contribute to RUQ pain if there's associated liver vein thrombosis or if the patient has a predisposition to clotting.
Budd-Chiari Syndrome: This condition, caused by hepatic vein thrombosis, can present with acute or chronic liver disease symptoms, including RUQ pain and peripheral edema due to liver congestion and subsequent hypoalbuminemia.

Hepatic Vein Thrombosis: Similar to Budd-Chiari syndrome, this condition can cause sudden onset of RUQ pain and edema. It's crucial to diagnose promptly due to the risk of liver failure and the need for anticoagulation.
Portal Vein Thrombosis: While often presenting with more chronic symptoms, portal vein thrombosis can cause acute RUQ pain and, in the context of cirrhosis or other liver diseases, contribute to peripheral edema.
Pulmonary Embolism with Right Heart Strain: Although primarily a respiratory emergency, a large pulmonary embolism can cause right heart strain, leading to peripheral edema and, potentially, referred RUQ pain due to liver congestion.

Constrictive Pericarditis: A condition where the pericardium becomes scarred and contracts around the heart, impeding its filling. It can cause peripheral edema and, due to increased venous pressure, liver congestion and RUQ pain.
Veno-occlusive Disease (Sinusoidal Obstruction Syndrome): Typically seen in the setting of bone marrow transplantation or certain medications, this condition causes small vein occlusion in the liver, leading to liver dysfunction, RUQ pain, and potentially peripheral edema.
Lymphoma or Other Malignancies: Certain cancers can cause both liver involvement (leading to RUQ pain) and lymphatic or venous obstruction (resulting in peripheral edema). These diagnoses are less common but should be considered, especially in patients with risk factors or systemic symptoms.