Can syphilis be transmitted through blood?

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Last updated: June 27, 2025View editorial policy

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From the Research

Yes, syphilis can be transmitted through blood, as the bacterium Treponema pallidum can be present in the bloodstream during certain stages of infection. This transmission can occur through blood transfusions from infected donors, sharing needles or other injection equipment with an infected person, or through occupational exposure to infected blood in healthcare settings 1. While sexual contact remains the most common route of transmission, blood-borne transmission is a recognized risk. The bacteria circulate in the bloodstream during primary and secondary syphilis, and sometimes during early latent syphilis, making blood-borne transmission possible.

Key Points to Consider

  • Blood donors are screened for syphilis to prevent transmission through blood transfusions 1
  • People with active syphilis cannot donate blood until they have completed treatment and been cleared by a healthcare provider
  • Treatment for syphilis typically involves antibiotics, most commonly penicillin G benzathine administered as an intramuscular injection, with the dosage and duration depending on the stage of infection 2
  • Other antibiotics like doxycycline, tetracycline, ceftriaxone, and azithromycin have been used to successfully treat syphilis, but penicillin remains the drug of choice in all stages of infection 2

Transmission and Prevention

Transmission of syphilis through blood highlights the importance of screening blood donors and preventing occupational exposure to infected blood in healthcare settings. It also underscores the need for safe sexual practices and the avoidance of sharing needles or other injection equipment.

Treatment and Management

The management of syphilis involves the use of antibiotics, with penicillin being the preferred choice. The dosage and duration of treatment depend on the stage of the infection. It is crucial to complete the full treatment course and follow up with a healthcare provider to ensure the infection is fully cleared.

References

Research

Syphilis in adults.

Sexually transmitted infections, 2005

Research

Syphilis: a reemerging infection.

American family physician, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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