From the FDA Drug Label
Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls Stopping Escitalopram tablets too quickly may cause serious symptoms including: ... headache, sweating, nausea, dizziness Discontinuation of Treatment with Escitalopram tablets ... anxiety, confusion, headache, lethargy, emotional lability, insomnia, and hypomania.
Headache is a possible side effect of Escitalopram, particularly when discontinuing treatment or in cases of hyponatremia. 1, 1, 1
From the Research
Yes, Lexapro (escitalopram) can cause headaches as a side effect. Headaches are among the more common side effects of Lexapro, affecting approximately 15-24% of people who take this medication. These headaches typically occur during the first few weeks of treatment and often diminish or disappear as your body adjusts to the medication. If you experience headaches while taking Lexapro, they can usually be managed with over-the-counter pain relievers like acetaminophen or ibuprofen 2. Staying hydrated and maintaining regular sleep patterns may also help reduce headache frequency. The headaches occur because Lexapro affects serotonin levels in the brain, which can temporarily influence blood vessel dilation and pain perception pathways. Some studies suggest that antidepressants, including selective serotonin reuptake inhibitors like Lexapro, can be used to treat migraine and other headache disorders 3, 4, 5. However, in the context of Lexapro causing headaches, it's essential to weigh the benefits of the medication against the potential side effects. If headaches are severe, persistent, or worsening over time, you should consult your healthcare provider, as they might recommend adjusting your dosage or switching to a different medication. Never stop taking Lexapro suddenly without medical supervision, as this can lead to withdrawal symptoms. It's also worth noting that some studies have investigated the use of combination therapy with antidepressants for patients with comorbid depression, migraine, and tension-type headache, which may be beneficial for some patients 5. Overall, while Lexapro can cause headaches, it's crucial to consider the individual patient's circumstances and medical history when making treatment decisions.