What is the treatment for aphthous ulcers?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 27, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the FDA Drug Label

Stop use and ask doctor or dentist if sore mouth symptoms do not improve in 7 days irritation, pain or redness persists or worsens swelling, rash or fever develops The treatment for aphthous ulcers is not directly stated in the provided drug label. Key points:

  • The label provides guidance on when to stop use and consult a doctor or dentist.
  • It does not provide a specific treatment for aphthous ulcers. 1

From the Research

The most effective treatment for aphthous ulcers is the use of 0.1% Triamcinolone Acetonide or 5% Amlexanox, as they have been proven to be more efficacious in reducing size, number, pain, erythema, and exudate levels compared to other treatments. When considering treatment options for aphthous ulcers, it's essential to prioritize the reduction of pain, inflammation, and healing time.

  • For mild cases, topical agents such as benzocaine or antimicrobial mouthwashes can provide symptomatic relief.
  • For more severe cases, topical corticosteroids like 0.1% Triamcinolone Acetonide 2 have been shown to be effective in reducing inflammation and promoting healing.
  • Additionally, 5% Amlexanox 2 has also been found to be effective in reducing the size and number of ulcers, as well as pain and erythema.
  • Other treatment options, such as topical anesthetics, nutritional supplements, and systemic medications, may also be considered, but their effectiveness may vary depending on the individual case.
  • It's also important to note that avoiding spicy, acidic, or rough foods and maintaining good oral hygiene can help prevent irritation and promote healing.
  • In severe or recurrent cases, medical evaluation is recommended to rule out underlying conditions that may require different treatment approaches, as suggested by various studies 3, 4, 5, 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.