From the Research
No, people with albinism do not naturally have high total bilirubin levels. Albinism is a genetic condition characterized by reduced or absent melanin production, affecting the pigmentation of the skin, hair, and eyes, but it does not directly impact liver function or bilirubin metabolism. Bilirubin is a yellow compound produced during the normal breakdown of red blood cells, and elevated levels typically indicate liver dysfunction, bile duct obstruction, or increased red blood cell destruction (hemolysis). The metabolic pathways responsible for bilirubin production, processing, and excretion operate independently from the genetic mutations that cause albinism, which primarily affect the tyrosinase enzyme or other proteins involved in melanin synthesis. If a person with albinism presents with high bilirubin levels, this would warrant the same medical investigation as in any other individual, as it would likely indicate an underlying condition unrelated to their albinism.
Some studies have investigated the relationship between bilirubin levels and various conditions, but none have found a direct link between albinism and high bilirubin levels. For example, a study on racial differences in serum total bilirubin levels found that blacks had lower mean bilirubin levels than whites, but this study did not involve individuals with albinism 1. Another study on the health benefits of elevated plasma bilirubin levels discussed the potential antioxidant effects of bilirubin, but did not address albinism specifically 2. A study on types of albinism in the black Southern African population provided information on the classification and clinical implications of different types of albinism, but did not mention bilirubin levels 3. A case report on hemolytic anemia as a cause of marked bilirubin increase in primary biliary cirrhosis highlighted the importance of considering other causes of hyperbilirubinemia, but was not related to albinism 4.
In summary, the available evidence does not suggest that people with albinism naturally have high total bilirubin levels, and any elevation in bilirubin levels in these individuals should be investigated as in the general population.