There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for acetaminophen (PO) do not address this question.
From the Research
Effectiveness of Acetaminophen for Zika Virus Infection
- Acetaminophen is considered for treating symptoms of Zika virus infection, as there is no specific antiviral treatment or vaccine available 1.
- A study found that several nonsteroidal anti-inflammatory drugs (NSAIDs), including acetaminophen, potently inhibited the entry of Zika virus Env/HIV-1-pseudotyped viruses and significantly inhibited the replication of wild-type ZIKV both in cell lines and in primary human fetal endothelial cells 2.
- The study proposed that NSAIDs, including acetaminophen, can be practically used for preventing ZIKV infection in pregnant women, as they are considered clinically safe 2.
- Another study mentioned that treatment of Zika virus infection focuses on managing symptoms with rest, fluids, and acetaminophen, with close monitoring for pregnant women 1.
- However, there is limited evidence on the effectiveness of acetaminophen for treating Zika virus infection specifically, and more research is needed to determine its efficacy.
Comparison with Other Treatments
- A case report suggested that high doses of intravenous vitamin C may be a potential treatment for acute viral infections, including Zika fever, with a patient showing resolution of symptoms after treatment 3.
- Another study found that the antimalarial drug amodiaquine possesses anti-Zika virus activities, with potential for treatment of ZIKV infection 4.
- A study on the common cold in adults found that acetaminophen may help relieve some symptoms, such as nasal obstruction and rhinorrhoea, but does not appear to improve other symptoms, such as sore throat, malaise, sneezing, and cough 5.