There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for olanzapine (PO), baclofen (PO) do not address this question.
From the Research
Recommended Dose and Duration of Olanzapine and Baclofen
- The recommended dose and duration of olanzapine and baclofen for the management of intractable hiccups are not well established, as there is limited evidence available in the literature 1, 2, 3.
- A case report suggests that a combination of baclofen and low-dose olanzapine therapy can be effective in controlling intractable hiccups 1.
- The exact dose and duration of baclofen used in this case report are not specified, but other studies suggest that baclofen can be effective in treating intractable hiccups at various doses 4, 5.
- A systematic review of pharmacological treatments for intractable and persistent hiccups found that baclofen, gabapentin, and metoclopramide were the most effective agents, but no specific recommendations can be made due to the limited evidence available 2.
- Another systematic review suggests that baclofen and gabapentin may be considered as first-line therapy for persistent and intractable hiccups, with metoclopramide and chlorpromazine in reserve 3.
Baclofen Dosage
- A double-blind, randomized, controlled, cross-over study found that baclofen was effective in treating intractable hiccups, but the exact dose used in the study is not specified 4.
- A case report found that a single oral dose of baclofen was effective in treating intractable hiccups, but the dose used is not specified 5.