Can albuterol (beta2-adrenergic agonist) administered via a nebulizer cause hallucinations?

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From the Research

Albuterol administered via nebulizer can potentially cause hallucinations, though this is considered a rare side effect, as evidenced by a case report from 1994 1. Albuterol is a beta2-adrenergic agonist commonly used to treat bronchospasm in conditions like asthma and COPD. While most side effects involve tremors, nervousness, headache, and increased heart rate, neuropsychiatric effects including hallucinations can occur, particularly at higher doses or in sensitive individuals. The mechanism likely involves central nervous system stimulation, as beta-adrenergic receptors are present in the brain. Children and elderly patients may be more susceptible to these effects. Hallucinations are more likely to occur with excessive use of the medication or in patients with underlying psychiatric conditions. If hallucinations develop while using albuterol, patients should contact their healthcare provider immediately, as dosage adjustment or medication change may be necessary. Some key points to consider:

  • The study from 1994 1 highlights the potential for hallucinations with excessive use of albuterol inhalers.
  • Other studies, such as those from 1984 2, 2014 3, 1999 4, and 2000 5, provide information on the pharmacology, efficacy, and safety of albuterol, but do not directly address the question of hallucinations.
  • It's essential to use albuterol as prescribed and not exceed recommended doses to minimize the risk of adverse effects.
  • Patients with underlying psychiatric conditions or those who are prone to excessive use of the medication should be closely monitored for signs of hallucinations or other neuropsychiatric effects.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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