From the Research
Tetrahydrocannabinol (THC) can induce psychoactive effects at doses as low as 2-3 milligrams for individuals with no tolerance, though this varies widely between people. For most adults, noticeable psychoactive effects typically begin at around 5-10 milligrams of THC. The onset and intensity of these effects depend on several factors including the method of consumption (inhalation produces effects within minutes while edibles take 30-90 minutes), individual body weight, metabolism, prior cannabis experience, and genetic factors affecting cannabinoid receptors. According to a study published in the Clinical journal of pain 1, oral dronabinol has similar psychoactive effects to smoking marijuana, with peak effects at 2 hours being similar to peak effects of smoked marijuana at 30 minutes. THC works by binding to cannabinoid receptors in the brain, particularly in regions responsible for memory, pleasure, coordination, and time perception. For those new to THC, it's advisable to start with a very low dose (2.5 mg or less) and wait for full effects before consuming more, as overconsumption can lead to anxiety, paranoia, and discomfort. Regular users develop tolerance, requiring higher doses to achieve the same effects over time. A study in Psychological medicine 2 found that cannabis affects people differently, with some individuals experiencing transient psychotic symptoms while others do not, highlighting the importance of individual variability in response to THC. It's also worth noting that the pharmacokinetics of THC can vary widely between individuals, with factors such as bioavailability, metabolism, and elimination all playing a role in determining the intensity and duration of psychoactive effects 3. Overall, the amount of THC required to induce psychoactive effects can vary significantly between individuals, and it's essential to approach THC use with caution and start with low doses to minimize the risk of adverse effects. Key factors to consider when using THC include:
- Method of consumption
- Individual tolerance
- Body weight
- Metabolism
- Prior cannabis experience
- Genetic factors affecting cannabinoid receptors. By taking these factors into account and starting with low doses, individuals can minimize the risks associated with THC use and maximize the potential benefits.