From the Research
Pityriasis rosea typically doesn't require treatment as it usually resolves on its own within 6-8 weeks. For symptom relief, over-the-counter antihistamines like diphenhydramine (25-50mg every 4-6 hours) or cetirizine (10mg daily) can help reduce itching, as suggested by general medical knowledge and practices 1, 2. Topical treatments such as calamine lotion, zinc oxide, or 1% hydrocortisone cream applied 2-3 times daily to affected areas can also alleviate itching. Some studies suggest that oral erythromycin may be effective in treating the rash and decreasing the itch, but this result should be treated with caution since it comes from only one small RCT 1. For more severe cases, a dermatologist might prescribe stronger topical corticosteroids or oral antihistamines. Lukewarm baths with colloidal oatmeal can soothe the skin, and wearing loose cotton clothing helps prevent irritation. Avoiding hot showers, harsh soaps, and excessive sun exposure is recommended as these can worsen symptoms. In rare cases where the rash is extensive or particularly uncomfortable, phototherapy with UVB light may be considered, as it has been shown to decrease the severity of the disease, although it does not affect the duration of the disease or the itching 3. The condition is believed to be triggered by a viral infection, particularly human herpesvirus 6 or 7, which explains why it typically resolves without specific antiviral treatment as the body's immune system addresses the underlying cause. A combination of ultraviolet irradiation and indigo naturalis treatment has been shown to be a safe and effective regime for control of PR, but further studies with large sample sizes are required to confirm these findings 4. Some other treatments like acyclovir can be used to treat symptoms and reduce the length of disease, but the evidence is not strong enough to make a definitive recommendation 2. In general, the treatment of pityriasis rosea should focus on relieving symptoms and waiting for the condition to resolve on its own.