What are the side effects of Ashwagandha (Withania somnifera)?

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Last updated: June 29, 2025View editorial policy

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From the Research

Ashwagandha (Withania somnifera) is generally considered safe, but it can cause several side effects, including mild and transient adverse events such as somnolence, epigastric pain/discomfort, and loose stools, as well as less common adverse events like giddiness, drowsiness, and nausea. The most recent and highest quality study, 1, found that Ashwagandha root extract was safe and well-tolerated in healthy adults, with no serious adverse events or changes in hematological, biochemical, or vital parameters reported. However, other studies have reported potential side effects, such as:

  • Digestive issues, including stomach upset, diarrhea, and nausea
  • Drowsiness, headaches, and dizziness
  • Lowered blood pressure and blood sugar levels, which could be problematic for those with hypotension or diabetes
  • Increased thyroid hormone levels, potentially causing issues for people with thyroid disorders
  • Potential interactions with medications, including sedatives, thyroid supplements, immunosuppressants, and blood pressure medications
  • Pregnant women should avoid ashwagandha due to its potential to cause miscarriage

It's essential to note that individual responses to ashwagandha can vary, and typical dosages range from 300-600 mg daily of root extract. If you experience concerning symptoms while taking ashwagandha, discontinue use and consult a healthcare provider. The bioactive compounds in ashwagandha, such as withanolides, can affect multiple body systems, and more research is needed to fully understand its effects on human health, as suggested by studies like 2 and 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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