From the Guidelines
Skullcap tops (Scutellaria lateriflora) are associated with dose-dependent sedation and have been designated by the FDA as an herb of undefined safety, making it crucial to be aware of potential side effects. The side effects of skullcap tops can vary, but common issues include drowsiness, dizziness, and mental confusion due to its sedative properties affecting the central nervous system 1. Some individuals may experience digestive issues such as nausea, stomach upset, or diarrhea when taking skullcap. More serious but less common side effects include liver damage, particularly with prolonged use or high doses, as some skullcap products have been associated with hepatotoxicity. Allergic reactions are possible, manifesting as skin rashes, itching, or in severe cases, difficulty breathing.
Key considerations for the use of skullcap tops include:
- Potential for additive CNS depressive effects in the perioperative period, suggesting that it should be held 2 weeks before surgery 1.
- Interaction with certain medications, particularly those affecting the central nervous system like sedatives, anti-anxiety medications, and anticonvulsants, potentially enhancing their effects.
- Lack of safety data for pregnant and breastfeeding women, advising against its use in these populations.
- Risk of side effects increasing with higher doses, and the potential for commercial products to be contaminated with other potentially harmful herbs.
Given the potential for significant side effects and interactions, it is recommended to approach the use of skullcap tops with caution, considering the benefits against the potential risks, especially in vulnerable populations or when combined with other medications. If you experience any concerning symptoms while taking skullcap, discontinue use and consult a healthcare provider immediately.
From the Research
Side Effects of Scutellaria lateriflora (Skullcap tops)
- Hepatotoxicity has been reported due to intentional or unintentional adulteration of Scutellaria lateriflora with Teucrium spp. 2
- There is no direct evidence of side effects of Scutellaria lateriflora itself, but it has been shown to have antioxidant, anti-inflammatory, and liver protective effects 3, 4, 5
- A study on Scutellaria baicalensis, a related species, found no significant changes in liver function tests after supplementation, suggesting that it may not be associated with hepatic dysfunction 6
- However, it is essential to note that the quality control of Scutellaria lateriflora products is crucial to prevent adulteration and ensure safety 2
- The potential side effects of Scutellaria lateriflora may include:
- Allergic reactions
- Interactions with other medications
- Exacerbation of underlying medical conditions
- However, these potential side effects are not supported by the available evidence and require further research
Important Considerations
- The quality of Scutellaria lateriflora products can vary depending on the manufacturer and source 2
- Adulteration with other plants, such as Teucrium spp., can occur and may lead to hepatotoxicity 2
- Further research is needed to fully understand the potential side effects and interactions of Scutellaria lateriflora 3, 4, 5