From the Research
Antipyretics may help decrease seizure episodes in benign myoclonic epilepsy of infancy, particularly when seizures are triggered by fever, but the most recent and highest quality evidence suggests that valproate is the treatment of first choice for this condition. The use of antipyretics, such as acetaminophen or ibuprofen, may be beneficial in reducing fever, which can lower the seizure threshold and make seizures more likely to occur 1. However, it is essential to note that antipyretics are not anti-seizure medications themselves and should be used alongside prescribed antiepileptic drugs rather than as a replacement.
Some key points to consider when treating benign myoclonic epilepsy of infancy include:
- Valproate is commonly the first choice alone or in combination with some benzodiazepines or levetiracetam 1
- The addition of ethosuximide to valproate can be helpful in some cases 2
- Lamotrigine can be effective therapy for some types of myoclonic epilepsy, but its use in benign myoclonic epilepsy of infancy is not well established 2, 1
- It is crucial to consult with a pediatric neurologist for a comprehensive treatment plan, as individual responses vary, and some children may require specific antiepileptic medications to effectively control their myoclonic seizures 3
In terms of the electroclinical features and long-term follow-up of patients with benign myoclonic epilepsy of infancy, studies have shown that:
- The ictal EEG typically shows a generalized discharge of polyspikes, polyspikes-and-waves, or spikes-and-waves 3
- The interictal EEG is usually normal 3
- Reflex myoclonic seizures are frequently observed, suggesting that two distinctive syndromes are not necessary 3
- The neuropsychological outcome is generally favorable, but mental retardation can be observed more frequently than in the general population 3