From the Research
No significant drug interactions exist between Augmentin (amoxicillin/clavulanic acid) and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) that would prevent their concurrent use. These medications can generally be taken together without dose adjustments. Augmentin is primarily eliminated through the kidneys, while the components of Genvoya are metabolized through different pathways, mainly involving the liver. Cobicistat, a component of Genvoya, is a CYP3A4 inhibitor, but amoxicillin/clavulanic acid is not significantly affected by this pathway, as supported by a study on the pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination 1. Patients should still inform their healthcare providers about all medications they are taking, as individual factors may occasionally necessitate monitoring. Both medications can cause gastrointestinal side effects like diarrhea or nausea, so patients should be aware that these symptoms might be more pronounced when taking both medications. Maintaining adequate hydration is important while on these medications, particularly since both can affect kidney function in some patients, as noted in a review of the efficacy and safety of Genvoya 2. It is also worth considering the properties of oral amoxicillin and clavulanic acid, including their metabolism and potential for gastrointestinal side effects, as discussed in a narrative review 3. However, the most recent and highest quality study does not indicate any significant interactions between Augmentin and Genvoya that would impact their concurrent use 2. Key points to consider include:
- The lack of significant drug interactions between Augmentin and Genvoya
- The potential for gastrointestinal side effects when taking both medications
- The importance of maintaining adequate hydration to minimize the risk of kidney function impairment
- The need for patients to inform their healthcare providers about all medications they are taking to ensure safe and effective treatment.