From the Research
Taking Xanax (alprazolam) as needed while on Wellbutrin (bupropion) and Cymbalta (duloxetine) requires medical supervision and is not something you should decide on your own. This combination can potentially increase side effects and risks, such as increased sedation, dizziness, and cognitive impairment, as both Cymbalta and Xanax affect brain chemicals that influence mood and anxiety 1. Additionally, Wellbutrin can sometimes increase anxiety in some people, which might lead to more frequent Xanax use. The combination of all three medications also increases the risk of serotonin syndrome, a potentially serious condition characterized by agitation, confusion, rapid heart rate, and high blood pressure. Some studies suggest that combining bupropion with serotonin reuptake inhibitors, like duloxetine, can be effective for treating major depressive disorder, but it also highlights the need for caution due to potential increased risks 2. It's essential to follow your doctor's prescription and guidance closely, as they have weighed the benefits against these risks for your specific situation. Always take these medications exactly as prescribed, don't adjust doses on your own, report any unusual side effects promptly, and avoid alcohol completely as it can dangerously enhance the sedative effects of Xanax when combined with these medications. Given the potential for adverse interactions, it's crucial to prioritize medical supervision to minimize risks and ensure the best possible outcome in terms of morbidity, mortality, and quality of life.