From the Research
Skin darkening around Copper-GHK injection sites is primarily caused by the copper component of the peptide complex, which stimulates melanin production and can lead to hyperpigmentation, as well as the inflammatory response triggered by the injection, which can contribute to post-inflammatory hyperpigmentation. The copper ions in the peptide complex can deposit in the tissue and oxidize, creating a bluish-gray discoloration known as localized cutaneous chrysiasis 1. This reaction is more common in individuals with darker skin tones or those who inject the compound frequently in the same area.
Some key points to consider:
- The copper component of the peptide complex is the primary cause of skin darkening around injection sites
- The inflammatory response triggered by the injection can contribute to post-inflammatory hyperpigmentation
- Individuals with darker skin tones or those who inject the compound frequently in the same area are more likely to experience skin darkening
- Rotating injection sites, using the lowest effective dose, and considering topical application instead of injection can help minimize this side effect
- Discontinuing use and consulting a healthcare provider is recommended if significant skin discoloration occurs, as it could indicate an adverse reaction to the compound
It's worth noting that while copper-free GHK has been shown to have similar effects to copper-GHK in terms of promoting skin regeneration and wound healing, the specific effects of copper-free GHK on skin darkening are not well understood 2. However, the most recent and highest quality study on this topic suggests that the copper component of the peptide complex is the primary cause of skin darkening around injection sites 1.
In terms of treatment options, depigmenting agents such as hydroquinone, azelaic acid, and kojic acid may be effective in reducing hyperpigmentation, as well as procedures such as chemical peeling and laser therapy 3. However, it's essential to consult a healthcare provider before starting any treatment, as they can help determine the best course of action and minimize the risk of adverse reactions.