From the Research
The trade name for cyclobenzaprine is Flexeril, which is also marketed under other brand names including Amrix, Fexmid, and FusePaq Tabradol. Cyclobenzaprine is a muscle relaxant medication primarily prescribed to relieve pain and discomfort caused by acute muscle spasms and musculoskeletal conditions. The medication works by acting on the central nervous system, specifically the brainstem, to reduce tonic muscle activity, as shown in a study published in 1. It is structurally similar to tricyclic antidepressants and shares some of their side effects, including drowsiness, dry mouth, and dizziness.
Some key points to consider when prescribing cyclobenzaprine include:
- The typical dosage is 5-10 mg taken three times daily, with treatment usually limited to 2-3 weeks due to limited evidence of effectiveness beyond this period, as noted in 2.
- Patients should be aware that this medication may impair driving ability and should avoid alcohol while taking it, as the combination can intensify sedative effects.
- Cyclobenzaprine has been shown to be effective in relieving muscle spasm and pain in patients with acute low back pain, as demonstrated in a study published in 3.
- However, it is also important to be aware of the potential risks of cyclobenzaprine toxicity, including rhabdomyolysis, as reported in a case study published in 4.
Overall, cyclobenzaprine is a useful medication for the treatment of acute muscle spasms and musculoskeletal conditions, but it should be used with caution and under the guidance of a healthcare professional.