From the Research
The recommended infusion rate for 66ml of medication to be administered over 90 minutes is 44ml per hour. To calculate this rate, I divided the total volume (66ml) by the total time in hours (90 minutes = 1.5 hours), which equals 44ml/hour. When programming an infusion pump, you would enter 44ml/hr as the rate. If using a manual gravity drip set with a standard drop factor of 20 drops/ml, you would need to deliver approximately 15 drops per minute (44ml/hr × 20 drops/ml ÷ 60 minutes = 14.7 drops/minute, rounded to 15). It's essential to monitor the infusion periodically to ensure the medication is being delivered at the correct rate and to check for any signs of infiltration or adverse reactions, as supported by studies such as 1 which discusses the safety of rapid infusions. The precise calculation of infusion rates is critical for medication safety, as incorrect rates can lead to under-dosing, overdosing, or inappropriate timing of therapeutic effects. Given the provided evidence, the most relevant and recent study to consider for infusion rates and safety is 2, which discusses the safety of infusing ipilimumab over 30 minutes, but for the specific calculation of infusion rate over 90 minutes, the general principle of dividing the total volume by the total time applies. Therefore, the focus should be on accurately calculating and administering the infusion rate to ensure patient safety and the effectiveness of the medication.