Differential Diagnosis for Skin Cracking and Peeling on Palms and Soles
Single Most Likely Diagnosis
- Eczema (Dyshidrotic Eczema/Pompholyx): This condition is characterized by small, itchy blisters on the palms and soles, which can progress to skin cracking and peeling. It's a common condition that can be triggered by stress, allergies, or environmental factors.
Other Likely Diagnoses
- Psoriasis: Palmar-plantar psoriasis can cause thickening, scaling, and cracking of the skin on the palms and soles. It's an autoimmune condition that can be managed with topical treatments and lifestyle changes.
- Contact Dermatitis: Irritant or allergic contact dermatitis can cause skin cracking and peeling on the palms and soles, especially if the individual is exposed to harsh chemicals or allergens.
- Hyperhidrosis: Excessive sweating can lead to skin maceration, cracking, and peeling, especially in the palmar and plantar regions.
Do Not Miss Diagnoses
- Syphilis: Secondary syphilis can cause a rash on the palms and soles, which can progress to skin cracking and peeling. It's essential to consider this diagnosis to prevent long-term complications and transmission.
- Keratoderma Blennorrhagicum: This is a rare condition associated with reactive arthritis, which can cause skin lesions and peeling on the palms and soles.
Rare Diagnoses
- Pityriasis Rubra Pilaris: A rare skin disorder that can cause skin cracking and peeling on the palms and soles, often accompanied by other systemic symptoms.
- Keratolysis Exfoliativa: A rare condition characterized by recurrent episodes of skin peeling on the palms and soles, often triggered by environmental factors or stress.
- Acrokeratosis Neoplastica: A rare paraneoplastic syndrome associated with skin lesions and peeling on the palms and soles, which can be a sign of an underlying malignancy.