Differential Diagnosis for Sweating Palm and Sole in 1 Year Old Baby

• Single most likely diagnosis
  • Hyperhidrosis: This condition is characterized by excessive sweating and can be primary (idiopathic) or secondary to another condition. In a 1-year-old baby, it might be primary hyperhidrosis, which can be familial. The condition typically presents with excessive sweating of the palms and soles.
• Other Likely diagnoses
  • Anxiety or stress response: Infants can exhibit physical responses to stress or anxiety, including sweating. This could be due to environmental factors or the infant's emotional state.
  • Overdressing or overheating: A common cause of sweating in infants, which can be easily overlooked. If the baby is overdressed or in a hot environment, it can lead to sweating, including on the palms and soles.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Congenital heart disease: Some congenital heart diseases can present with sweating, among other symptoms like poor feeding, failure to thrive, or respiratory distress. Although less common, it's crucial to consider due to its severity.
  • Thyrotoxicosis: Although rare in infants, thyrotoxicosis (an overactive thyroid gland) can cause excessive sweating, among other symptoms like irritability, poor sleep, and weight loss.
• Rare diagnoses
  • Familial dysautonomia (Riley-Day syndrome): A rare genetic disorder that affects the development of the autonomic nervous system, leading to various symptoms including excessive sweating.
  • Pheochromocytoma: A rare tumor of the adrenal gland that can cause excessive sweating, hypertension, and other symptoms. It is extremely rare in infants but should be considered in the differential diagnosis due to its potential severity.