From the Guidelines
Testosterone gel can be applied in the evening, as long as a consistent schedule is maintained. While morning application is traditionally recommended, there is no specific guideline that restricts application to the morning, and evening application is also acceptable 1. When applying testosterone gel, it is essential to use the prescribed amount on clean, dry skin of the recommended areas, such as the back, abdomen, upper thighs, and upper arms, and allow it to dry completely before covering with clothing. Some key points to consider when applying testosterone gel in the evening include:
- Applying at the same time each day helps maintain stable hormone levels 1
- Avoiding washing the area for several hours after application
- Minimizing the risk of transfer to partners or children during daytime activities by applying in the evening
- Being aware of potential sleep disturbances after evening application and considering switching to morning use if necessary It is crucial to follow the healthcare provider's specific instructions regarding the particular testosterone gel product being used, as different products may have varying application instructions and recommendations 1.
From the FDA Drug Label
Starting dose of testosterone gel 1.62% is 40.5 mg of testosterone (2 pump actuations or a single 40.5 mg packet), applied topically once daily in the morning.
The FDA drug label does not answer the question.
From the Research
Testosterone Gel Application Timing
- The provided studies do not specifically address the optimal timing of testosterone gel application, such as morning or evening [(2,3,4,5,6)].
- However, the studies discuss the application of testosterone gel at various times, including morning 4 and twice a day 6, but do not compare the efficacy of application at different times of the day.
- It is essential to follow the recommended application schedule and dosage as prescribed by a healthcare professional to ensure the safe and effective use of testosterone gel 5.
Application Site and Dosage
- The application site and dosage of testosterone gel can affect its absorption and efficacy [(2,4)].
- Studies have investigated the application of testosterone gel to different body sites, including the arms, shoulders, chest, abdomen, and thighs [(2,4)].
- The dosage of testosterone gel can also impact its effectiveness, with higher doses not always resulting in greater increases in testosterone levels 4.
Safety and Side Effects
- Testosterone gel can cause side effects, such as skin irritation, acne, and polycythemia [(3,5)].
- The risk of testosterone transfer to other individuals, such as partners or family members, is considered low 3.
- Regular monitoring of prostate-specific antigen, hematocrit, and lipid levels is recommended for patients taking testosterone gel 5.