What is the price of Tri-Luma (fluocinolone acetonide, hydroquinone, tretinoin)?

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Last updated: July 3, 2025View editorial policy

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From the Research

The price of Tri-Luma cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) typically ranges from $200 to $300 for a 30-gram tube in the United States, though costs can vary significantly depending on location, pharmacy, and insurance coverage. This prescription medication is used to treat melasma, a skin condition causing dark patches on the face. Many insurance plans may not fully cover Tri-Luma as it's considered a cosmetic treatment, resulting in high out-of-pocket expenses.

  • Patients should check with their insurance provider about coverage and consider using pharmacy discount cards or manufacturer coupons to reduce costs.
  • Generic versions may be available at lower prices.
  • Additionally, compounding pharmacies can sometimes create similar formulations at reduced costs, though quality and consistency may vary. Due to its expense, patients should follow application instructions carefully to avoid wasting product and maximize the treatment's effectiveness, as supported by studies such as 1 which evaluated the safety and efficacy of a triple combination cream for treatment of melasma. However, the provided studies do not directly address the pricing of Tri-Luma, but rather its efficacy and safety in treating melasma, as seen in studies like 2, 3, 4, and 5.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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