From the FDA Drug Label
Data from in vitro studies of benzodiazepines other than alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine. Caution is recommended during the coadministration of any of these with alprazolam (see WARNINGS)
It is recommended to exercise caution when taking Xanax (alprazolam) and nifedipine together, as there is a possible drug interaction. The FDA drug label suggests that nifedipine may interact with alprazolam, although the clinical significance of this interaction is not fully understood. To minimize potential risks, patients should be closely monitored for adverse effects, and the dosage of either medication may need to be adjusted. Patients should consult their physician before taking these medications together 1.
From the Research
Taking Xanax (alprazolam) and nifedipine together is generally considered safe, but should be done under medical supervision. These medications don't have a major interaction that would prevent their combined use, as supported by the lack of direct evidence on their interaction in the provided studies 2, 3, 4, 5, 6. However, both medications can potentially lower blood pressure, so taking them together might enhance this effect, possibly causing symptoms like dizziness or lightheadedness, especially when standing up quickly. Nifedipine is a calcium channel blocker used primarily for high blood pressure and certain heart conditions, while Xanax is a benzodiazepine used for anxiety disorders. Elderly patients should be particularly cautious with this combination as they may be more sensitive to these effects.
Some key points to consider when taking these medications together include:
- Monitoring blood pressure regularly to avoid hypotension
- Being aware of potential side effects such as dizziness or lightheadedness, especially when changing positions
- Avoiding alcohol, which could worsen side effects
- Never adjusting dosages or stopping either medication without consulting a doctor first
The most recent study on nifedipine, from 2016 6, evaluated the safety of immediate-release nifedipine and found that although it may cause major adverse events, the incidence seems lower than previously believed, suggesting that with proper supervision, the combination of Xanax and nifedipine could be managed safely. It's crucial to follow the healthcare provider's instructions and report any unusual side effects promptly to ensure the best outcome.