From the Research
Males should avoid taking selective serotonin reuptake inhibitors (SSRIs) while trying to conceive due to potential negative effects on sperm parameters and fertility, as suggested by the most recent and highest quality study available 1. When considering the use of antidepressants in males trying to conceive, it's essential to weigh the potential benefits of treatment against the potential risks to fertility.
- The most recent study from 2022 1 suggests that SSRIs can decrease the number and viability of sperm, and cause a disruption of their morphological structure, which could negatively impact fertility.
- Another study from 2020 2 also found that SSRIs, particularly fluoxetine, can have gonadotoxic effects, including decreased sperm concentration and motility, increased DNA fragmentation, and decreased reproductive organ weights.
- However, it's worth noting that the effects of SSRIs on male fertility may be reversible, and some studies suggest that alternative antidepressants like mirtazapine or bupropion may have lower potential to cause sexual side effects and could be considered as alternatives 1.
- In terms of specific medications, fluoxetine and sertraline, two commonly prescribed SSRIs, have been shown to impair sperm function in vitro, with fluoxetine consistently decreasing progressive motility and promoting fluctuations in ROS levels and sperm capacitation 3. Overall, while the evidence is not entirely conclusive, the most recent and highest quality study suggests that males should avoid taking SSRIs while trying to conceive due to potential negative effects on sperm parameters and fertility.
- If antidepressant treatment is necessary, alternative medications with fewer sexual side effects, such as bupropion, may be considered under medical supervision 1, 2.