From the Guidelines
Men who are trying to conceive should avoid taking St. John's Wort (Hypericum perforatum) due to its potential effects on sperm quality and hormone levels, as well as its interactions with other medications. The most recent and highest quality study on male infertility, published in 2024 1, does not specifically address the use of St. John's Wort, but it highlights the importance of evaluating and treating underlying conditions that may affect male fertility. Previous studies have suggested that St. John's Wort may alter levels of neurotransmitters like serotonin and influence testosterone production and sperm parameters, although research specifically on male fertility is limited 1. Additionally, St. John's Wort is known to interact with many medications through its effect on liver enzymes, which could complicate fertility treatments if those are being used 1. If you're currently taking St. John's Wort for depression or anxiety, consult with your healthcare provider about alternative treatments that are safer while trying to conceive. Other lifestyle factors that can positively impact male fertility include:
- Maintaining a healthy weight
- Avoiding excessive alcohol and tobacco
- Limiting exposure to environmental toxins
- Managing stress through methods other than herbal supplements. It's essential to prioritize evidence-based treatments and consult with a healthcare provider before making any changes to your medication or supplement regimen.
From the Research
St. John's Wort and Conception
- There is limited research on the effects of St. John's Wort on male fertility and conception 2, 3, 4, 5, 6.
- The available studies focus on the antidepressant effects of St. John's Wort, its mechanism of action, and potential interactions with other medications 3, 4, 5, 6.
- One study examined the effect of antenatal exposure to St. John's Wort on the neurobehavior of developing mice, but it did not investigate the impact on male fertility or conception specifically 2.
- Another study discussed the potential interactions between St. John's Wort and other medications, including oral contraceptives, but it did not address the issue of male fertility or conception 3.
- The current evidence does not provide a clear answer to whether males can take St. John's Wort while trying to conceive, and more research is needed to fully understand its effects on male fertility and conception.
Potential Interactions and Effects
- St. John's Wort may interact with other medications, including those used to treat depression, and its use should be carefully considered and monitored 3, 4, 6.
- The herb has been shown to have antidepressant effects, but its mechanism of action is not fully understood, and more research is needed to determine its potential effects on male fertility and conception 4, 5.
- Some studies suggest that St. John's Wort may have a favorable safety profile compared to conventional antidepressants, but its use should still be approached with caution and under the guidance of a healthcare professional 4, 6.