From the Guidelines
It is not recommended to use Wegovy (semaglutide) that has not been stored in the fridge, as its effectiveness and safety may be compromised due to degradation of the peptide medication at higher temperatures. According to the properties of GLP-1RA, semaglutide has a specific pharmacokinetic profile, with a total dose range of 0.25 - 4.5 mg and an elimination half-life of 7 days 1. The medication is typically stored in the refrigerator at 36°F to 46°F (2°C to 8°C) until first use, and after first use, the pen can be kept at room temperature between 59°F to 86°F (15°C to 30°C) for up to 28 days. Some key points to consider when storing Wegovy include:
- Storage conditions: Refrigerate at 36°F to 46°F (2°C to 8°C) until first use
- Room temperature storage: Up to 28 days after first use, between 59°F to 86°F (15°C to 30°C)
- Potential risks of improper storage: Degradation of the medication, reduced efficacy, and potential bacterial contamination If Wegovy has been left unrefrigerated beyond these guidelines, it is best to contact your healthcare provider for guidance and not use the medication, as it may not provide the intended therapeutic effect or could potentially cause harm 1.
From the FDA Drug Label
Store the WEGOVY single-dose pen in the refrigerator from 2°C to 8°C (36°F to 46°F). If needed, prior to cap removal, the pen can be kept from 8°C to 30°C (46°F to 86°F) up to 28 days. Do not freeze. Protect WEGOVY from light. Throw away the pen if WEGOVY has been frozen, has been exposed to light or temperatures above 86°F (30°C), or has been out of the refrigerator for 28 days or longer.
It is not recommended to use Wegovy that has not been stored in the fridge if it has been out of the refrigerator for more than 28 days or has been exposed to temperatures above 86°F (30°C) or frozen.
- If the pen has been stored at room temperature (up to 86°F or 30°C) for less than 28 days, it is okay to use.
- However, if the pen has been stored improperly, it is recommended to discard the pen and use a new one to ensure the quality and efficacy of the medication 2.
From the Research
Storage and Handling of Wegovy
- The provided studies do not directly address the storage and handling of Wegovy (3, 4, 5, 6, 7).
- None of the studies mention the specific storage conditions for Wegovy, such as the need for refrigeration.
- The studies primarily focus on the efficacy, safety, and ethical considerations of semaglutide (Wegovy) for weight loss and type 2 diabetes management.
General Information on Semaglutide
- Semaglutide, sold under the brand names Ozempic, Rybelsus, and Wegovy, is a glucagon-like peptide-1 receptor agonist used for type 2 diabetes and weight loss (3, 4, 6).
- The drug has shown promise in encouraging glycemic control and promoting weight loss in patients with or without type 2 diabetes (4, 6).
- However, the studies do not provide information on the storage and handling of Wegovy, including whether it can be used if not stored in the fridge.
Conclusion Not Available
As per the instructions, no conclusion can be drawn, and the user should consult the official packaging or manufacturer's guidelines for information on the storage and handling of Wegovy.