From the Research
Dimenhydrinate (Gravol) can be used while breastfeeding, but with caution and under the guidance of a healthcare provider, as the most recent and highest quality evidence does not directly address its safety in breastfeeding mothers. When considering the use of Gravol during breastfeeding, it's essential to weigh the benefits of the medication for the mother against the potential risks to the infant. The transfer of medications into breast milk depends on several factors, including the concentration gradient, the drug's ability to pass through cell membranes, and its protein binding properties 1.
Given the lack of direct evidence on dimenhydrinate in the provided studies, we must consider general principles of drug transfer into breast milk. Drugs that are poorly absorbed orally, have a short half-life, and are not highly lipid-soluble tend to be safer during breastfeeding because they are less likely to accumulate in the infant 2, 3. However, dimenhydrinate has anticholinergic properties, which could potentially decrease milk supply, especially with higher doses or prolonged use.
To minimize exposure to the infant, breastfeeding mothers taking Gravol should:
- Use the lowest effective dose for the shortest duration necessary to manage symptoms.
- Consider timing doses right after nursing to minimize the amount of drug in milk during the next feeding.
- Monitor the infant for any signs of unusual drowsiness, irritability, or feeding problems.
For frequent or severe nausea and vomiting, it's advisable to consult a healthcare provider, who may recommend alternative medications with a more established safety profile during breastfeeding or help identify and treat the underlying cause of the symptoms 4, 3. The decision to use any medication during breastfeeding should be made in consultation with a healthcare provider, taking into account the most current and comprehensive information available, such as that found in resources like LactMed 3.