What is the evidence for using ashwagandha for stress relief and anxiety?

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From the Research

Ashwagandha supplementation significantly reduces anxiety and stress levels, and its use is recommended for stress relief and anxiety reduction, with a recommended dosage of 300-600mg daily of a standardized extract. The evidence from recent studies, such as the 2022 systematic review and meta-analysis 1, supports the effectiveness of ashwagandha in reducing anxiety and stress levels. This study found that ashwagandha supplementation significantly reduced anxiety (SMD: -1.55,95% CI: -2.37, -0.74; p = .005; I2 = 93.8%) and stress level (SMD: -1.75; 95% CI: -2.29, -1.22; p = .005; I2 = 83.1%) compared to the placebo.

Some key points to consider when using ashwagandha for stress relief and anxiety reduction include:

  • The recommended dosage typically ranges from 300-600mg daily of a standardized extract (containing 1.5-5% withanolides)
  • Ashwagandha should be taken for at least 6-8 weeks for optimal results
  • Most studies show significant reductions in cortisol levels and anxiety scores compared to placebo, with improvements often noticeable after 4 weeks of consistent use
  • Ashwagandha works primarily as an adaptogen, helping the body resist various stressors by modulating stress hormone production and supporting neurotransmitter function
  • Side effects are generally mild and may include digestive discomfort, drowsiness, or headaches
  • It's essential to purchase from reputable brands that test for purity and standardize their extracts
  • Those taking medications for thyroid conditions, diabetes, high blood pressure, or immunosuppressants should consult healthcare providers before use, as should pregnant or breastfeeding women
  • For best results, take ashwagandha with food, either as a single dose or divided throughout the day

Other studies, such as the 2012 randomized double-blind, placebo-controlled study 2 and the 2019 double-blind, randomized, placebo-controlled clinical study 3, also support the effectiveness of ashwagandha in reducing stress and anxiety. However, the 2022 systematic review and meta-analysis 1 provides the most recent and highest quality evidence, and its findings should be prioritized when making recommendations. Additionally, a 2022 qualitative analysis of a double-blind randomized control trial 4 found that ashwagandha increased college students' perceived well-being through supporting sustained energy, heightened mental clarity, and enhanced sleep quality. Another study from 2017 5 found that ashwagandha root extract can be used for body weight management in adults under chronic stress.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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