From the Research
To naturally improve Thyroid Peroxidase (TPO) antibody levels, consider supplementing with selenium (200 mcg daily) as it has been shown to decrease TPO antibody concentrations in patients with autoimmune thyroiditis. This approach is supported by a study published in The Journal of Clinical Endocrinology and Metabolism 1, which found that selenium supplementation reduced TPO antibody levels by 40% in patients with high antibody levels.
Key Considerations
- Selenium supplementation has been found to improve the inflammatory activity in patients with autoimmune thyroiditis, especially in those with high activity 1.
- A gluten-free diet may also be beneficial, as gluten sensitivity can trigger autoimmune responses in susceptible individuals.
- Increasing consumption of anti-inflammatory foods like fatty fish, colorful vegetables, fruits, nuts, seeds, and olive oil, while reducing processed foods, refined sugars, and industrial seed oils, can help reduce systemic inflammation and support immune function.
- Managing stress through regular meditation, yoga, or deep breathing exercises, and prioritizing quality sleep and moderate exercise, can also help optimize thyroid health.
Additional Recommendations
- Consider supplementing with vitamin D (2000-4000 IU daily if deficient) and zinc (15-30 mg daily) to support immune function and thyroid health.
- Work with your healthcare provider to monitor your antibody levels and adjust your thyroid medication as needed.
- Note that while these natural methods can be beneficial, they should complement, not replace, conventional medical treatment.
Evidence Summary
The study by 1 provides the strongest evidence for the use of selenium supplementation to improve TPO antibody levels. Other studies, such as those published in 1990 2, 1994 3, 2019 4, and 2000 5, provide additional context and support for the importance of nutritional factors and immune function in thyroid health, but the 2002 study 1 is the most relevant and highest-quality study for this specific question.