From the Guidelines
DHEA supplementation can increase estrogen levels in men, and its use should be approached with caution, particularly in those with hormone-sensitive conditions. When considering DHEA supplementation, it is essential to understand that the body can convert some of this hormone into estrogen through a process called aromatization 1. This conversion happens because DHEA serves as a precursor to both testosterone and estrogen in the body.
Key Considerations
- Typical DHEA supplement doses range from 25-50mg daily, with higher doses (100mg or more) more likely to cause significant estrogen conversion.
- Men considering DHEA supplementation should be aware of potential side effects related to increased estrogen, including gynecomastia (breast tissue development), water retention, and mood changes.
- Older men may be particularly susceptible to these effects as natural aromatase enzyme activity tends to increase with age.
- Before starting DHEA, men should consider getting baseline hormone levels tested and should monitor for estrogen-related side effects during supplementation.
Recommendations
- Those with hormone-sensitive conditions like prostate issues should exercise particular caution and consult with a healthcare provider before using DHEA 1.
- Given the potential risks and uncertainties associated with DHEA supplementation, particularly regarding its impact on estrogen levels, a cautious approach is warranted, prioritizing the monitoring of hormone levels and potential side effects 1.
From the Research
DHEA Supplementation and Estrogen Levels in Men
- The effect of DHEA supplementation on estrogen levels in men is a topic of interest, with some studies suggesting an increase in circulating estrogens 2.
- A study published in 1999 found that oral administration of DHEA in elderly men led to a significant increase in circulating estrogens, including 17beta-estradiol and estrone, in a dose-dependent manner 2.
- Another study published in 1997 found that DHEA administration in men caused an increase in the circulating levels of DHEA and its sulfate, as well as an increase in the conjugated metabolites of dihydrotestosterone, but no consistent change in serum estrone or estradiol 3.
- However, a study published in 1998 found that DHEA supplementation in age-advanced men did not lead to a significant increase in serum estrogen levels, but rather an increase in serum androgen levels, including androstenedione and dihydrotestosterone 4.
- It is worth noting that the study published in 2002 mentions that the effects of DHEA could be estrogenic or androgenic, depending on the hormonal milieu, but does not provide specific information on the effect of DHEA supplementation on estrogen levels in men 5.
- The study published in 2010 discusses the role of DHEA as a source of sex steroids in men and women, but does not provide specific information on the effect of DHEA supplementation on estrogen levels in men 6.