From the Guidelines
The first symptoms of Reye's syndrome are typically characterized by protracted vomiting, followed by lethargy, which is usually the first neurological manifestation, and may also include diarrhea and hyperventilation in children younger than two years. According to the study published in Thorax in 2007 1, Reye’s syndrome is marked by an acute non-inflammatory encephalopathy with an altered level of consciousness, elevation of ammonia levels, and hepatic dysfunction. The neurological symptoms usually occur 24–48 hours after the onset of vomiting. Key early signs include:
- Protracted vomiting
- Lethargy
- Diarrhea and hyperventilation in children younger than two years
- Unusual drowsiness
- Confusion, irritability, combativeness, and disorientation as the condition progresses. It is essential to seek immediate medical attention if these symptoms appear, as Reye's syndrome can rapidly progress to seizures, coma, and potentially death 1.
From the FDA Drug Label
Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reyes syndrome, a rare but serious illness The first symptoms of Reye's syndrome are changes in behavior, nausea, and vomiting 2.
From the Research
Symptoms of Reye's Syndrome
The first symptoms of Reye's syndrome can vary depending on the age of the patient.
- In children and adolescents, the symptoms typically start with a prodromal viral illness, such as influenza A or B or chicken pox, followed by:
- In infants, the symptoms may be more subtle and can include:
- Diarrhea
- Respiratory disturbances
- Seizures 3
- Other symptoms that have been reported in patients with Reye's syndrome include: