From the Research
Methylfolate is generally safe for men to take as a supplement, with a recommended dosage of 15 mg daily for those with diagnosed folate deficiency or major depressive disorder, as supported by the most recent and highest quality study 1. When considering methylfolate supplementation, it's essential to understand the different forms of folate and their bioavailability. Methylfolate, or 5-methyltetrahydrofolate (5-MTHF), is the active form of folate that's more readily used by the body compared to folic acid, making it particularly beneficial for those with impaired folate metabolism 2. Some key points to consider when taking methylfolate as a supplement include:
- Typical recommended dosages range from 400-1000 mcg (0.4-1 mg) daily for general health maintenance
- Men with certain genetic variations like MTHFR mutations may benefit from slightly higher doses of 800-1000 mcg daily
- For those with diagnosed folate deficiency, healthcare providers might recommend doses up to 5-15 mg daily for a limited treatment period, as seen in the study by 1
- Side effects are uncommon at standard doses but may include sleep disturbances, irritability, or headaches in some individuals It's crucial to start with a lower dose and increase gradually if needed, and to consult with a healthcare provider before starting any supplement, especially for men with existing health conditions or those taking medications that might interact with folate metabolism 1.