From the Research
A good ratio of N-Acetylcysteine (NAC) to Alpha-Glyceryl Phosphoryl Choline (Alpha GPC) in a stack is typically 2:1 or 3:1, with approximately 600-1200 mg of NAC paired with 300-400 mg of Alpha GPC daily, as supported by the antioxidant and hematological properties of NAC 1 and the cognitive enhancement benefits of Alpha GPC 2. When considering the optimal ratio, it's essential to balance the benefits of both supplements. NAC's role as an antioxidant and glutathione precursor supports its higher proportion in the ratio, while Alpha GPC provides sufficient choline support for cognitive function without oversupplementation.
- The higher proportion of NAC is based on its ability to elevate reduced glutathione (GSH) levels and improve hematological parameters, such as erythropoietin (EPO), hemoglobin (Hb), and hematocrit (Hct) 1.
- Alpha GPC, on the other hand, has been shown to enhance cognitive function and neurogenesis, particularly when administered after a seizure or other neurological insult 2.
- The combination of NAC and Alpha GPC can be taken in divided doses, such as half in the morning and half in the afternoon, with food to minimize potential gastrointestinal discomfort.
- Individual responses may vary, so starting at the lower end of the dosage range and gradually increasing as needed is recommended, while monitoring for any side effects such as headaches, digestive issues, or unusual stimulation.
- It's also important to note that the safety profile of NAC at high doses is similar to that at standard doses, with gastrointestinal symptoms being the most common adverse effect 3.