What is the treatment for Mononucleosis (Mono)?

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Treatment for Infectious Mononucleosis (Mono)

The treatment for infectious mononucleosis (Mono) is primarily supportive care, as there is no specific antiviral therapy routinely recommended for this self-limited condition. 1, 2

Diagnosis Confirmation

Before initiating treatment, confirm the diagnosis with:

  • Complete blood count with differential (looking for >40% lymphocytes and >10% atypical lymphocytes)
  • Heterophile antibody test (Monospot test) - sensitivity 87%, specificity 91%
    • Note: False negatives may occur in children <5 years and adults in the first week of illness
  • If heterophile test is negative but clinical suspicion remains high, check for elevated liver enzymes or consider EBV viral capsid antigen antibody testing 3

Supportive Care Treatment Protocol

First-line Management

  • Adequate hydration to prevent dehydration
  • Analgesics/antipyretics for fever and pain control:
    • Acetaminophen for fever and sore throat
    • NSAIDs for myalgias and pharyngeal discomfort
  • Adequate rest guided by the patient's energy level (do not enforce strict bed rest) 2

Activity Restrictions

  • Avoid contact sports or strenuous exercise for at least 3-8 weeks or while splenomegaly is present
  • Return to normal activities should be gradual and based on patient's energy levels
  • Shared decision-making should guide return to athletic activity 3, 4

Monitoring for Complications

  • Monitor for signs of splenic enlargement
  • Assess for respiratory compromise or severe pharyngeal edema that might require additional intervention
  • Be alert for rare complications such as spontaneous splenic rupture (0.1-0.5% of cases) 1

Special Considerations

When to Consider Corticosteroids

Corticosteroids are not recommended for routine treatment but may be beneficial in specific situations:

  • Severe pharyngeal edema with risk of airway obstruction
  • Significant respiratory compromise
  • Massive splenomegaly
  • Hemolytic anemia or severe thrombocytopenia 2

Medications Not Routinely Recommended

  • Antivirals (including acyclovir): Not effective for routine EBV infectious mononucleosis
  • Antihistamines: No proven benefit
  • Routine corticosteroids: Not indicated unless specific complications present 2

Patient Education

  • Inform patients that fatigue may persist for several months after acute infection resolves
  • Advise about the risk of splenic rupture and importance of avoiding contact sports
  • Explain that EBV is primarily transmitted through saliva ("kissing disease")
  • Reassure that most patients have an uneventful recovery 1, 4

Follow-up

  • Clinical reassessment at 3-4 weeks to evaluate for resolution of splenomegaly before clearing for contact sports
  • Additional follow-up as needed for persistent symptoms
  • Most patients will have complete resolution of symptoms within 2-4 weeks, though fatigue may persist longer 4

The prognosis for infectious mononucleosis is generally excellent, with most patients experiencing complete recovery without specific antiviral treatment. The focus should remain on supportive care and monitoring for rare complications.

References

Research

Infectious Mononucleosis: An Updated Review.

Current pediatric reviews, 2024

Research

Epstein-Barr virus infectious mononucleosis.

American family physician, 2004

Research

Infectious Mononucleosis: Rapid Evidence Review.

American family physician, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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