Timing Between Prilosec (Omeprazole) and Other Medications
After taking Prilosec (omeprazole), you should wait at least 2 hours before taking most other medications, and at least 4 hours after taking medications that require stomach acid for absorption. 1
How Prilosec Affects Medication Absorption
Omeprazole (Prilosec) is a proton pump inhibitor (PPI) that works by reducing stomach acid production. This reduction in stomach acid can affect how other medications are absorbed in your body:
Mechanism of Action
- Prilosec begins working within 30-60 minutes of ingestion
- Peak plasma concentrations occur within 1-3 hours
- Effects on stomach acid can last up to 72 hours, though the drug is cleared from plasma within 3-4 hours 2
Specific Waiting Times by Medication Type
Medications Requiring Stomach Acid for Absorption
Wait at least 4 hours after taking Prilosec before taking:
- Antifungals (ketoconazole, itraconazole)
- Iron supplements
- Certain antibiotics
- Thyroid medications
Medications That Bind to Stomach Contents
Wait at least 2 hours before or 4-6 hours after taking:
- Antacids
- Sucralfate
- Bile acid sequestrants 1
Medications With No Significant Interaction
These can generally be taken without special timing considerations:
- Most antibiotics
- Pain medications
- Blood pressure medications
- Most other medications not listed above
Special Considerations
For Antacids
- Take at least 2 hours before or 2 hours after Prilosec 1
- Antacids can reduce the absorption of Prilosec if taken simultaneously
For H2 Blockers (Famotidine, Ranitidine)
- Avoid taking together with Prilosec as they may interfere with each other's effectiveness 1
- If both are prescribed, take Prilosec at least 30 minutes before the H2 blocker
For Medications Affected by Cytochrome P450 Enzymes
Prilosec can potentially interact with medications metabolized by the hepatic cytochrome P450 system:
- Diazepam
- Phenytoin
- Warfarin
- Clopidogrel
Common Pitfalls to Avoid
Taking all medications at the same time as Prilosec - This can reduce the effectiveness of both Prilosec and other medications
Assuming all PPIs have the same interaction profile - Different PPIs may have different interaction profiles
Not informing healthcare providers about Prilosec use - Always tell your doctor and pharmacist about all medications you take, including over-the-counter drugs
Stopping Prilosec abruptly - This can lead to rebound acid hypersecretion
Practical Approach to Medication Timing
- Take Prilosec 30-60 minutes before breakfast for optimal effect
- Wait at least 2 hours before taking most other medications
- For medications requiring stomach acid for absorption, wait at least 4 hours
- For antacids, take them at least 2 hours before or after Prilosec
- If you're unsure about specific medication interactions, consult your pharmacist or healthcare provider
Following these guidelines will help ensure that both Prilosec and your other medications work as effectively as possible.